Multi-part tutorial question C
John Slack is a colleague of yours who did not pay attention in Pharmacology. He now wishes he did because he does not understand some important points about his client’s combination pill of Candesartan and Hydrochlorothiazide.
Explain them to him, by answering the four sub-questions of this multi-part tutorial question in a total of less than 700 words.
Sub-question A:(4 points):
Briefly explain the renin- angiotensin aldosterone mechanism, placing the ‘…pril’ and ‘…sartan’ drugs into the context of that explanation include the actions of angiotensin II and the results of those actions.
Sub-question B (1 point):
Briefly discuss the reason Candesartan is often preferred over ACE inhibitors.
Sub-question C (3 points):
Describe the mechanism of action, the indications, contraindications and side effects of candesartan.
Sub-question D (2 points):
Using the fixed pill combinations of candesartan and hydrochlorothiazide as an example, explain some of the overall advantages of fixed pill combinations of drugs. Briefly discuss the most important side effect of candesartan- hydrochlorothiazide combined pills.
Note: Answer in own words. No references needed.